Perindopril is a long-acting ACE inhibitor.
For Hypertension
4 mg once daily, then the dose may be increased to 8 mg after 1 month of treatment to improve blood pressure control or in case of concomitant stable coronary artery disease.
In Australia, l is available as perindopril arginine. In hypertension, the initiation dose is 5 mg once daily, then the dose may be increased to 10 mg after 1 month of treatment to improve blood pressure control or in case of concomitant stable coronary artery disease.
The Anglo-Scandinavian Cardiac Outcomes Trial showed the benefits of taking the two drugs Perindopril and amlodipine together. The 9000 British patients aged 40 to 79 were involved in the five-year trial. Half were given the new drug combination, the rest were given traditional drugs. Perindopril and amlodipine were found to be so effective that the trial was stopped early so that all patients could receive the combination.
For Stable coronary artery disease
A starting dose of 4 mg for 2 weeks is recommended, then uptitration to 8 mg once daily, depending on acceptability.
Congestive heart disease
Coversyl (perindopril) should be started under close medical supervision at a starting dose of 2 mg. This may be increased to 4 mg once blood pressure acceptability has been demonstrated.
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Elderly patients should start treatment at 2 mg daily (2.5 mg daily (perindopril arginine) in Australia).
Contraindications include; children, pregnancy, lactation and situations where a patient has a history of hypersensitivity to perindopril |
